| Title | Publisher | Year | Language | Documents |
|---|---|---|---|---|
| Sarvegne | Eric Forgeot | 2006 | French | Solution |
| Schatten Über London | Martin Vincenz | 2006 | German | |
| Season of the Sakura | Triumph Game Labs | 2006 | English | |
| Simple Adventure | Paul Allen Panks |
2006 | English | |
| Sisters, The | revgiblet | 2006 | English | Solution |
| Sisyphus | Theo Koutz | 2006 | English | |
| Star City | Mark Sachs | 2006 | English | Solution |
| Strange Geometries | Phillip Chambers | 2006 | English | Solution |
| Sugared Pill, A | Colin Borland | 2006 | English | Solution |
| Sword and the Fate | Adramelek | 2006 | Russian |