| Title | Publisher | Year | Language | Documents |
|---|---|---|---|---|
| Madam Spider's Web | Sara Dee | 2006 | English | Solution |
| Malaise | A. Ninny | 2006 | English | |
| MANALIVE, A Mystery of Madness - I | Bill Powell | 2006 | English | Solution |
| MANALIVE, A Mystery of Madness - II | Bill Powell | 2006 | English | Solution |
| Mansion II, The | Nick Dablin | 2006 | English | |
| Mision Espacial | Beyker Soft | 2006 | Spanish | |
| Möbius | J. D. Clemens | 2006 | English | Solution |
| Moments Out of Time: Adventure Type | L. Ross Raszewski | 2006 | English | Solution |
| Moments Out of Time: RENEGADE Type | L. Ross Raszewski | 2006 | English | |
| Moon-Shaped | Jason Ermer | 2006 | English | Solution |
| Mundo Feliz, Un | Ancient Bits | 2006 | Spanish |